A hybrid discrete-continuum model of immune responses to SARS-CoV-2 infection in the lung alveolar region, with a focus on interferon induced innate responseArticle Published on 2022-12-212022-11-15 Journal: Journal of theoretical biology [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] adaptive alveolar alveolar cells antibodies antibody antibody concentration baseline Cell cell death Cellular automaton COVID-19 develop diffusion domain Efficacy Future Gas exchange healthy human lung Immune cell immune protection immune response Immunity infected cell Infection initial Innate innate immune Innate immunity innate response Interaction interferon interferons lung alveolar maintain manuscript mechanism Model multiple mechanism outcome Pneumonia produced profiles progression Result RNA copy SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant simulations. Spread Strains submitted switching T cells the SARS-CoV-2 virus two-dimensional type I Viral load virion virions [DOI] 10.1016/j.jtbi.2022.111293 PMC 바로가기
SARS-CoV-2 viral load is associated with risk of transmission to household and community contactsSARS-CoV-2 바이러스 부하는 가정 및 지역사회 접촉자에게 전파될 위험과 관련이 있습니다.Article Published on 2022-08-052022-09-11 Journal: BMC Infectious Diseases [Category] SARS, 변종, [키워드] 95% CI Adjusting association Asymptomatic Chain Reaction Chi-square chi-square tests close contact Community Contact Contact tracing cough COVID-19 Cycle threshold value Cycle threshold values described evaluate exposure Factor Factors Generalized high viral load index index case index cases investigated likelihood log Median viral load physical contact polymerase chain polymerase chain reaction positive pre-symptomatic proportion proportions public health measure public health measures quarantine recommendation Research risk factor Risk factors risk of transmission RNA copy Saliva SARS-CoV-2 transmission SARS-CoV-2 viral load scaled significantly test result tested tracing Transmission variant variants Viral load Viral load. viral loads were used [DOI] 10.1186/s12879-022-07663-1 PMC 바로가기 [Article Type] Article
Evaluation of Antiviral Effect against SARS-CoV-2 Propagation by Crude Polysaccharides from Seaweed and Abalone Viscera In Vitro해조류 및 전복 내장의 조다당류에 의한 SARS-CoV-2 증식에 대한 시험관내 항바이러스 효과 평가Article Published on 2022-04-272022-09-11 Journal: Marine Drugs [Category] COVID19(2023년), SARS, 치료법, 치료제, [키워드] Abalone abalone viscera addition Antiviral antiviral activity Antiviral effect COVID-19 discus Effect evaluated expression level followed by Haliotis immunofluorescence assay inhibit SARS-CoV-2 inhibited inhibitory effect Interference nucleocapsid Nucleocapsid proteins plaque Plaque titration polysaccharide polysaccharides Propagation Quantitative Replication RNA copies RNA copy RT-PCR analysis Sargassum SARS-CoV-2 SARS-CoV-2 propagation SARS-CoV-2 replication SARS-CoV-2 spikes seaweed seaweed. Treatment Vero E6 VERO E6 cells viral entry viral infection viscera western blot [DOI] 10.3390/md20050296 PMC 바로가기 [Article Type] Article
Link between SARS-CoV-2 emissions and airborne concentrations: Closing the gap in understandingSARS-CoV-2 배출과 공기 중 농도 간의 연결: 이해의 격차 해소Article Published on 2022-04-152022-09-11 Journal: Journal of hazardous materials [Category] COVID19(2023년), SARS, 치료기술, [키워드] Airborne SARS-CoV-2 concentration Airborne virus transmission Analysis approach Comparative analysis Concentration conducted COVID-19 emission Evidence Health hospital Metrological compatibility analysis. Nasopharyngeal swab Predictive provided regulatory authority Result resulting RNA copies RNA copy room SARS-CoV-2 shown subject the SARS-CoV-2 threshold Transmission transmission of SARS-CoV-2 Viral load virus [DOI] 10.1016/j.jhazmat.2022.128279 PMC 바로가기 [Article Type] Article
Exploration of the ocular surface infection by SARS-CoV-2 and implications for corneal donation: An ex vivo studySARS-COV-2에 의한 안구 표면 감염의 탐색 및 각막 기증에 대한 시사점 : 생체 외 연구Research Article Published on 2022-03-012022-09-10 Journal: PLoS Medicine [Category] MERS, SARS, 치료기술, [키워드] 24 hour 24 hours ACE-2 acute respiratory syndrome aims Algorithms angiotensin angiotensin-converting enzyme 2 bulbar conjunctiva cathepsin cellular entry Conjunctiva Contamination contraindication contraindications Cornea Corneal Corneal Graft Corneal transplantation coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 crisis Ct value Culture culture media decrease diagnosed diagnosed with COVID-19 Donor Donor selection donors enzyme epithelial cell epithelial cells epithelium evaluate Evidence Ex vivo exacerbated exploration expresse expressed expression expression of SARS-CoV-2 expression pattern female genetic material healthy donor immunohistochemistry implication IMPROVE increase in Infection infectious dose inoculation involved lack limbus limited sample size mandatory media median moderate molecular mRNA level nasopharyngeal Nasopharyngeal swab nasopharyngeal swabs Not contaminated Ocular surface organ organ culture pandemic pathway Patient PCR positive Positive test Postinfection promote promoted Protein qPCR quantified quantitative PCR question RdRP receptor Replication researcher respiratory respond retrieved reverse transcription Reverse transcription quantitative PCR risk risk of transmission RNA RNA copy RNA sequence RT-qPCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 receptors SARS-CoV-2 RNA SARS-CoV-2 viral SARS-CoV-2 virus Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significant increase Support TCID tested tissue tissue culture tissues TMPRSS2 Transmission utility Viral Viral detection Viral RNA was tested were infected worsened [DOI] 10.1371/journal.pmed.1003922 PMC 바로가기 [Article Type] Research Article
Comparative Evaluation of Rapid Isothermal Amplification and Antigen Assays for Screening Testing of SARS-CoV-2SARS-CoV-2의 선별 검사를 위한 급속 등온 증폭 및 항원 분석의 비교 평가Article Published on 2022-02-252022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Antigen antigen test Asymptomatic clinical sample clinical samples collected Comparative COVID-19 Ct values evaluated greater Health Human individual isothermal isothermal amplification isothermal molecular test Lateral flow test limit of detection mass vaccination molecular nasal swab occur outbreak positive Public qPCR Rapid Rapid test reaction reduce reduced RNA copy SARS-CoV-2 Screening sensitivity specimen Surveillance symptomatic Testing testing. transmission of SARS-CoV-2 vaccination variants of concern virus spread [DOI] 10.3390/v14030468 PMC 바로가기 [Article Type] Article
Impaired detection of omicron by SARS-CoV-2 rapid antigen testsSARS-CoV-2 신속 항원 검사에 의한 오미크론 검출 장애Original Article Published on 2022-02-202022-09-10 Journal: Medical Microbiology and Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 치료기술, 치료법, [키워드] analytical sensitivity Awareness B.1.1.529 B.1.617.2 Cell Cell culture collected comparable country Ct values detection rate diagnostic test driven by dropped evaluated examined globe highest Impaired Infection infection rate infection rates isolate Laboratory lateral flow limit of detection National nine nucleocapsid protein omicron pandemic PCR-negative PCR-positive point-of-care tests positive positive test result Predictive Predictive value ranged rapid antigen test Rapid antigen tests RAT RATs reduced required respiratory RNA copies RNA copy SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 rapid antigen test sensitivity specificity specimen suggested supplementary material swab sample test results the SARS-CoV-2 variant virus load virus stock VoC [DOI] 10.1007/s00430-022-00730-z PMC 바로가기 [Article Type] Original Article
Postmortem Stability of SARS-CoV-2 in Mouse Lung TissueResearch Letter Published on 2021-12-012022-10-31 Journal: Emerging Infectious Diseases [Category] COVID-19, SARS, [키워드] 2019 novel coronavirus disease acute respiratory syndrome Antigen coronavirus coronavirus disease Coronaviruses COVID-19 death Deceased declined determine Experimental infection hACE2 Host Infectious virus K18 K18 hACE2 mice lung mice mouse organism Postmortem respiratory infections RNA copy RT-PCR SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 TCID50 transgenic virus infectivity viruses zoonoses [DOI] 10.3201/eid2712.211621 PMC 바로가기 [Article Type] Research Letter
COVID-19 wastewater epidemiology: a model to estimate infected populationsCOVID-19 폐수 역학: 감염 인구를 추정하는 모델Article Published on 2021-12-012022-09-11 Journal: The Lancet. Planetary health [Category] Fulltext, SARS, 치료기술, [키워드] 95% CI aligned approach can be used Clemson University collected Community confidence limit confirmed case confirmed cases Control COVID-19 COVID-19 cases Department detection Epidemiology geographical area identify independent individual individuals infected individual infected individuals Infection limitation Model number of infected overcome per day Population predict Prevalence provide provided released RNA concentration RNA copies RNA copy robust SARS-CoV-2 RNA SEIR South tested transmission of SARS-CoV-2 USA virus wastewater [DOI] 10.1016/S2542-5196(21)00230-8 PMC 바로가기 [Article Type] Article
Rates of viral suppression in a cohort of people with stable HIV from two community models of ART delivery versus facility-based HIV care in Lusaka, Zambia: a cluster-randomised, non-inferiority trial nested in the HPTN 071 (PopART) trial잠비아 Lusaka의 ART 전달과 시설 기반 HIV 치료의 두 가지 커뮤니티 모델에서 안정적인 HIV를 가진 사람들의 바이러스 억제 비율 : HPTN 071 (POPART) 시험에 중첩 된 클러스터 랜덤 화, 비 회개 시험.Articles Published on 2021-11-262022-09-06 Journal: The Lancet. HIV [Category] Communicable Disease, [키워드] 95% CI Abuse AIDS allergy Antiretroviral therapy ART assigned Care clinic clinician club Cohort Community Coverage death defined drug Drug Abuse effective Effectiveness eligible Emergency enrolled enrolment Evidence feasibility Final finding Follow-up for inclusion foundation funding group had no HBD health condition HIV Impact individual Infectious diseases initiative less Melinda Gate Melinda Gates mental health National non-inferiority margin non-inferiority trial participant Participants patients plan President Prevalence primary endpoint Primary outcome proportion provided Randomly Rate receiving relief risk risk difference RNA copy screened SOC Standard of care Support suppressed Treatment Trial Viral Viral load virological suppression with HIV written Informed Consent zone [DOI] 10.1016/S2352-3018(21)00242-3 PMC 바로가기 [Article Type] Articles